This study aims to prepare hybrid chitosan-alginate aerogel microparticles without using\nadditional ionic crosslinker as a possible pulmonary drug delivery system. The microparticles were\nprepared using the emulsion gelation method. The effect of the mixing order of the biopolymer within\nthe emulsion and the surfactant used on final particle properties were investigated. Physicochemical\ncharacterizations were performed to evaluate particle size, density, morphology, surface area,\nsurface charge, and the crystallinity of the preparation. The developed preparation was evaluated for\nits acute toxicity in adult male Sprague-Dawley rats. Measurements of zeta potential suggest that the\nsurface charge depends mainly on the surfactant type while the order of biopolymer mixing has less\nimpact on the surface charge...........................
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